Overview All individuals who need to access the Animal Management protocol must be entered on the Personnel page. Personnel must be U-M employees, U-M students, or have U-M Friend accounts. Only the people listed on this page and approved with the application may conduct the animal experimental procedures. All questions must be answered and all fields filled out in order to submit the application.
Overview During the review process, reviewers add questions to an application in order to request clarification on or additional information about the protocol. These questions are routed through the ACU Office Research Compliance Associate (RCA) where they are reviewed, summarized and then sent to the Principal Investigator (PI).
Overview The Principal Investigator (PI) is the person responsible for the protocol application. The PI’s name and contact information must be entered before the application can be created and saved. Only one PI is allowed per application. All questions must be answered and fields filled out in order to submit the application.
Overview The Agent/Substance Summary page includes a “view only” list of all Agents and Substances administered to animals as indicated throughout the Protocol. Changes must be made directly on the corresponding Procedure(s) pages. For questions regarding the security, storage, and/or disposal of Controlled Substances, please contact the Controlled Substance Monitors for additional information.
Overview Compare functionality replaced the “View Differences” interface as of eRAM version 5.0 in May 2021. 
Overview Amendments are created for approved or suspended protocols when any part of the protocol requires a change. Depending on the type of change, the amendment may or may not need to go through the full review process. Important Information Personnel, Scientific, and PI Change amendments require updates to Animal Handling Details.
Overview Laboratory animals are expected to be maintained under species-specific living conditions. Federal regulations specify the parameters for the following: a) social housing; b) temperature of room/environment; c) enrichment; d) cage size; and e) cage sanitization.  Species-specific standard practices conducted by ULAM staff adhere to the federal regulations.  Deviations from these standard conditions require justification.
Overview All projects must have an internal and/or external sponsor/funding source. PIs and protocol editors will be able to associate their protocol to multiple funding sources including grants. Users can associate to any grant in the eResearch Proposal Management (eRPM) system. However, there will be a confirmation that the associated grant is applicable for the protocol.
Overview Humane endpoints, which contribute to refinement, are the earliest point at which pain or distress in an experimental animal can be prevented, terminated, or relieved. When pain or distress is a potential or expected consequence of any animal activity, humane endpoints must be established. Appropriate monitoring of all animals is required to address animal health and well-being before they reach their humane endpoints.